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September 17, 2025Universal Journal of Pharmaceutical Research0 citationsOpen Access

Comparative Study of Three Brands of Slidenafil Citrate Tablets in Sudanese Markets

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FMFatehalrahman F. MagboolMIMahmoud A. IbrahimASAbdul Sami

Key Points

  • The study found significant differences in active ingredient content across three brands of sildenafil citrate tablets.
  • Brand E & F showed similarities in physical characteristics, but disintegration rates differed, affecting their interchangeability.
  • Quality evaluation was conducted using HPLC to assess factors like dissolution profile and friability in the tablets.
  • Improper quality assurance could lead to serious health risks, particularly in pediatric patients treated for pulmonary hypertension.

Abstract

Aim and Objectives: This study assessed the quality of Sildenafil citrate tablet products, whether locally produced or imported, available in the Sudanese market, aiming to determine their potential interchangeability in clinical use. Methods: The quality evaluation of the drug products covered physical and organoleptic characteristics, along with tests for weight variation, friability, hardness, disintegration time, dissolution profile, and determination of Sildenafil content. The assay was performed using the standard HPLC method. Results: Findings indicated that the similarity between brand E Reviewed 11 July 2025; Accepted 20 August; Available online 15 September 2025 Academic Editor: Dr. A. A. Mgbahurike, University of Port Harcourt, Nigeria, amakaₘgbahurike@yahoo. com Reviewers: Aya Mohammed Mohammed Essawy, MTI University- Mokattam, Egypt, aya. essawy@gmail. com Dina Abd Elfattah Eldakhs, Pharos university (PUA), Egypt, dinaₑldakhs@yahoo. com

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Cite This Study

Magbool et al. (2025) studied this question.

synapsesocial.com/papers/68d45e6231b076d99fa5ede6https://doi.org/10.22270/ujpr.v10i4.1387
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