Abstract Introduction: Colorectal cancer (CRC) remains a leading cause of preventable cancer mortality, with persistent screening disparities in underserved communities. This qualitative study aimed to identify community-specific barriers and facilitators to CRC screening among residents of Baltimore public housing to inform the development of tailored educational materials. Methods: We conducted three in-person focus groups with 16 adults residing in two Baltimore City public housing communities. Semi-structured guides explored screening knowledge, perceived barriers, trusted information sources, and preferences for educational content and delivery. Sessions investigated participants' understanding of CRC risk factors, screening options, and procedural concerns. Discussions were audio-recorded, transcribed, and analyzed by two researchers using thematic analysis to identify major themes and inform material development. Results: Key barriers included deep-seated medical mistrust stemming from historical and personal negative healthcare experiences, stigma surrounding colorectal procedures (particularly among men), confusion about screening options and procedures, and significant logistical challenges. Participants expressed frustration with scheduling delays ("I had to wait 3 months for my first one...a lot could happen in 3 months"), transportation difficulties ("You can't go on your own. You have to have somebody to go with you"), and communication barriers including medical jargon ("Put it in...plain English so we can understand"). Many participants felt their concerns were dismissed by providers, creating additional barriers to care. Facilitators to screening uptake included family history awareness, clear provider communication, peer support, and culturally resonant messaging from trusted community sources. Participants emphasized the importance of plain language, visual aids, and community-specific references. These included outreach strategies including door-to-door flyers with varied levels of medical detail, community information sessions that include meals, and practical guidance on CRC prevention through dietary changes and healthy eating patterns. Conclusions: This study elucidates the value of community-engaged approaches in developing CRC screening education. Tailoring materials to reflect local knowledge, concerns, and communication preferences may improve screening uptake and reduce disparities. These findings provide a foundation for future interventions and health education in similar underserved settings. Citation Format: Celia Marion, Robyn N. Jordan, Tonya Rosebrough, Alison P. Klein, Zachariah Foda. Community-informed development of educational materials to improve colorectal cancer screening uptake in underserved Baltimore populations abstract. In: Proceedings of the 18th AACR Conference on the Science of Cancer Health Disparities; 2025 Sep 18-21; Baltimore, MD. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34(9 Suppl):Abstract nr B060.
Marion et al. (2025) studied this question.