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September 24, 2025Cureus0 citationsOpen Access

Infectious Mimics of Bell's Palsy: Facial Nerve Palsy Due to Lyme Neuroborreliosis

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TMTha MonANAye NyeinAOAung Oo

Key Points

  • Diagnosis of bilateral FNP revealed Lyme neuroborreliosis after thorough clinical evaluation and testing.
  • Patient treated with IV ceftriaxone showed significant improvement in facial nerve function.
  • Highlighting early detection of LNB is crucial for favorable outcomes in affected patients.
  • Facial nerve palsy can have various causes, with Lyme disease being a critical infectious mimic.

Abstract

Facial nerve palsy (FNP) is a common neurological disorder. There are multiple causes of FNP, and Bell's palsy is defined as an idiopathic cause of FNP. If a patient presents with facial palsy, a full investigation workup should be performed. Lyme disease can present with erythema migrans, fever, headache, muscle and joint pain, and facial palsy. We present a case of a 47-year-old man who presented with progression from unilateral to bilateral FNP. After a series of investigations, he was diagnosed with LNB. Even if MRI findings are normal, cerebrospinal fluid (CSF) analysis and Lyme serology (enzyme-linked immunosorbent assay followed by Western blot) in serum and/or CSF can confirm the diagnosis of neuroborreliosis. We have administered the patient IV ceftriaxone 2 g daily, as per the guidelines. He showed gradual improvement in FNP from House-Brackmann Grade V to Grade II on subsequent follow-ups. This case emphasizes the importance of broad clinical evaluation in diagnosing FNP. Early detection of LNB and initiation of treatment can ensure patients have a favorable outcome.

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Cite This Study

Mon et al. (2025) studied this question.

synapsesocial.com/papers/68d6e16f8b2b6861e4c4012chttps://doi.org/10.7759/cureus.93122
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Diagnosis and Treatment of Idiopathic Facial Paresis (Bell’s Palsy)2019 · 192 citations
  2. 2Bell's palsy: diagnosis and management.2007 · 249 citations
  3. 3The impact of misdiagnosing Bell’s palsy as acute stroke2019 · 38 citations
  4. 4Bilateral Facial Palsy: A Clinical Approach2021 · 22 citations
  5. 5Prevalence and spectrum of residual symptoms in Lyme neuroborreliosis after pharmacological treatment: a systematic review2015 · 104 citations