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September 28, 2025New England Journal of Medicine2 citations

Herpes Simplex Virus Esophagitis

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AAAnkit AgarwalAAAshish Agarwal

Key Points

  • Patient experienced painful swallowing and had prior fever, indicating potential viral etiology.
  • Endoscopy revealed multiple ulcers in the esophagus, specifically described as 'volcano-like', which is characteristic of herpes infection.
  • This case emphasizes the need for clinicians to consider herpes simplex virus esophagitis in young patients with similar symptoms.
  • Further investigation may be required for similar presentations to confirm diagnosis and initiate appropriate treatment.

Abstract

A 29-year-old woman presented with a 2-day history of painful swallowing. One week earlier, she had had a fever and sore throat. Upper endoscopy revealed multiple "volcano-like" ulcers in the middle esophagus.

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Cite This Study

Agarwal et al. (2025) studied this question.

synapsesocial.com/papers/68d90a0a41e1c178a14f683chttps://doi.org/10.1056/nejmicm2502014
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Herpes simplex esophagitis in immunocompetent patients: a rare entity to consider.2026
  2. 2Herpes Simplex Virus Esophagitis in an Immunocompetent Patient: A Case Report2024 · 2 citations
  3. 3Herpes simplex virus esophagitis in immunocompetent patients: a case report and updated literature review2026
  4. 4Herpes Simplex Virus Esophagitis in an Immunocompetent Patient: Navigating Diagnostic Challenges and Achieving Effective Treatment2026
  5. 5Dysphagia and chest pain in a 7-year-old girl2024