Background Gonadotropin-releasing hormone (GnRH) antagonist and long-acting GnRH agonist regimens are commonly employed for ovarian stimulation in women undergoing in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), but their relative efficacy in improving pregnancy outcomes remains controversial. Previous studies has yielded conflicting results, leaving clinicians and researchers uncertain about which protocol is more favorable. Given the high prevalence of infertility and the importance of improving pregnancy outcomes for these patients, understanding the differences in the efficacy of these two protocols is crucial. Therefore, our study aims to conduct a direct comparison of pregnancy outcomes between patients using GnRH antagonist protocol or long-acting GnRH agonist protocol.
Zhao et al. (2025) studied this question.