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Introduction and objective. Cutaneous lesions developing within tattoos is a well-recognized, relatively rare manifestation of sarcoidosis. Lower socioeconomic status is associated with greater skin disease severity in sarcoidosis patients. Therefore, the objective of this retrospective, single-site study was to determine whether residing in disadvantaged neighborhoods in Chicago, Illinois may espouse tattoo-associated sarcoidosis. Methods. 20 patient charts at the University of Illinois Hospital in Chicago were found to have tattoos and biopsy-proven cutaneous sarcoidosis. The patients were categorized according to presence or absence of noncaseating granulomas consistent with sarcoidosis located within tattoo pigmentation. Patients’ Chicago zip codes were ranked by socioeconomic disadvantage using the validated University of Wisconsin-Madison Area Deprivation Index (ADI) where an affluent neighborhood had a score of ≤5 and a disadvantaged neighborhood had a score >5. Analysis utilized Welch’s t-test. P0.05). Conclusions. Tattoo-associated sarcoidosis was correlated to patients residing in affluent neighborhoods in Chicago. However, the mechanism(s) underlying this phenomenon was not found. Prospective, multi-site randomized studies are warranted to corroborate these findings.
Whittington et al. (2024) studied this question.