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September 11, 2024Environmental Science & Technology34 citationsOpen Access

Neurotoxic Effects of Mixtures of Perfluoroalkyl Substances (PFAS) at Environmental and Human Blood Concentrations

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KRKarla M. Ríos-BonillaDADiana S. AgaJLJungeun Lee

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Abstract

Per- and polyfluoroalkyl substances (PFAS) may cause various deleterious health effects. Epidemiological studies have demonstrated associations between PFAS exposure and adverse neurodevelopmental outcomes. The cytotoxicity, neurotoxicity, and mitochondrial toxicity of up to 12 PFAS including perfluoroalkyl carboxylates, perfluoroalkyl sulfonates, 6:2 fluorotelomer sulfonic acid (6:2 FTSA), and hexafluoropropylene oxide-dimer acid (HPFO-DA) were tested at concentrations typically observed in the environment (e.g., wastewater, biosolids) and in human blood using high-throughput

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Ríos-Bonilla et al. (2024) studied this question.

synapsesocial.com/papers/68e58cbfb6db6435875282b9https://doi.org/10.1021/acs.est.4c06017
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