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Marjolin's ulcers are cutaneous malignancies that arise from chronic wounds, often secondary to burns. While squamous cell carcinoma is the most prevalent type, rare instances of other tumors, such as basal cell carcinoma, have occurred. These tumors are challenging to treat due to their high recurrence rate and aggressive behavior. In this report, we present the case of a 76-year-old male with a history significant for polysubstance use, human immunodeficiency virus (HIV), hepatitis C, and Agent Orange exposure who presented with a large fungating basal cell carcinoma secondary to a non-healing wound. Additionally, several other cutaneous malignancies were present, including a large verruciform squamous cell carcinoma adjacent to a Marjolin's ulcer. These lesions were managed with surgical excision, followed by radiation therapy due to suboptimal margins.
Latta et al. (2024) studied this question.