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A new method entitled alternating Look-Locker (aLL) for mapping of T1 and T1ρ is proposed. Magnetization preparation modules incorporating adiabatic full passage pulses were imbedded in a Look-Locker scheme that additionally alternates magnetization from +Z and -Z axes. MB-SWIFT was used as a readout. Analytical derivations and relevant simulations are presented. Phantom experiments and in vivo studies in the rat brain were conducted at 9.4 T. Results show that aLL allows more robust and faster acquisitions as compared to previously introduced steady–state technique, providing the possibility of simultaneous collection of T1 and T1ρ maps in one acquisition.
Wu et al. (2024) studied this question.