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Advanced acquisition hardware and sequences boosting the spatiotemporal resolution overcome the existing limitations of HP metabolic MRI in animal disease models, providing new contrasts and opening up new perspectives. Herein, we designed a 1H/13C volume/surface-combined head coil providing full mouse brain coverage with high sensitivity, as well as a high-efficiency acquisition scheme to achieve superior spatial and temporal resolution images. This setup was employed for time-resolved imaging of the cerebral metabolic response to a neuroprotective bolus of hyperpolarized pyruvate in a transient hypoxia/ischemia mouse model. The experiments suggest a distinct metabolism between the ischemic and healthy tissues.
Lê et al. (2024) studied this question.