A case of systemic lupus erythematosus with antineutrophil cytoplasmic antibodies positive skin vasculitis and concomitant combined thrombophilia

We present a case study of a 31-year-old man diagnosed with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS).His medical history included fever, malar rash, arthritis, pulmonary embolism and deep vein thrombosis.He had elevated antinuclear antibodies (ANA) titer (1:640; reference range, <1:160), and positive anticardiolipin antibodies in IgG and IgM classes, as well as anti-B2-glucoprotein I antibodies in IgM class antibodies, confirmed in subsequent tests (Supplementary material, Table S1).Initial treatment with systemic glucocorticoids (SGCs) resulted in clinical improvement.