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June 24, 2024Biomedicine & Pharmacotherapy37 citationsOpen Access

Gentiopicroside improves NASH and liver fibrosis by suppressing TLR4 and NLRP3 signaling pathways

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QYQiuhong YongCHChaoyuan HuangBCBonan Chen

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Abstract

Non-alcoholic steatohepatitis (NASH) and liver fibrosis are progressive conditions associated with non-alcoholic fatty liver disease (NAFLD), characterized by hepatocyte pyroptosis and hepatic stellate cell (HSC) activation. Gentiopicroside (GPS) has emerged as a potential treatment for NASH, yet its underlying mechanism remains unclear.

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Yong et al. (2024) studied this question.

synapsesocial.com/papers/68e637ebb6db6435875c962ehttps://doi.org/10.1016/j.biopha.2024.116952
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