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The experimental dissociation constant (pKa) value of paracetamol is presented in this work. Drugs' dissociation constant (pKa), is one of their most significant physicochemical characteristics. When considering dosage form design and pharmacological analysis, it is extremely important. A UV-visible spectrophotometric technique was mainly employed to determine the pKa of paracetamol. Considering that spectrophotometric pKa determination yields the most accurate values, the spectrophotometric methods was used for the pKa determination. It was found that the pKa of paracetamol was 4.9, 9.9, and 10.5, then understanding a substance's dissociation constant is crucial for a variety of applications and research fields.
Radad et al. (2024) studied this question.