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June 3, 2024Alzheimer s & Dementia14 citationsOpen Access

Expansion of highly interferon‐responsive T cells in early‐onset Alzheimer's disease

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DSDaniel W. SirkisCSCaroline Warly SolsbergTJTaylor P. Johnson

Key Points

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Abstract

Altered immune signatures are emerging as a central theme in neurodegenerative disease, yet little is known about immune responses in early-onset Alzheimer's disease (EOAD).

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Cite This Study

Sirkis et al. (2024) studied this question.

synapsesocial.com/papers/68e665f2b6db6435875f21d5https://doi.org/10.1002/alz.13892
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Altered T cell reactivity to β-amyloid-related antigens in early Alzheimer’s disease2024
  2. 2Adaptive immune changes associate with clinical progression of Alzheimer’s disease2024 · 18 citations
  3. 3Cross‐tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer's disease2026
  4. 4Cross-tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer’s disease2025
  5. 5Type I interferon drives T cell responses to amyloid beta in the central nervous system2026 · 2 citations