Key points are not available for this paper at this time.
Supplementary Figure S15. Heatmaps representing the normalised concentration of the metabolites and the metabolite ratios significantly represented across timepoints (A) and across responders and non-responders (B). Normalisation was performed using the sample with highest metabolite concentration from each row as reference (100%). The complete list of metabolites analysed can be found in Suppl.Tab.5. Abbreviations: EOT, End of Treatment; 12w, 12 weeks; Tyr/Phe, Tyrosine/Phenylalanine; Met-SO/Met, Methionine-sulfoxide/Methionine; AC-DC, acylcarnitine derivative of a dicarboxylic acid.
Pinato et al. (2024) studied this question.