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An unprecedented protocol for the synthesis of 1,2,4-oxadiazoles from carbamates has been developed by employing nitriles as both substrates and solvents. This one-pot procedure achieves the formation of C═N bonds via TFA-mediated 3+2 annulation. A series of 1,2,4-oxadiazoles are synthesized in moderate to good yields.
Zhuang et al. (2024) studied this question.