0877 Sleep Quality and Dyslipidemia Among Young and Midlife Women

Abstract Introduction Sleep quality is associated with poor cardiometabolic health in women and men. However, these associations have been infrequently reported among young and midlife women. Therefore, we examined the influence of poor sleep quality on dyslipidemia in a cohort of women from Michigan. Methods We utilized the POUCHmoms Study, a large and socioeconomically diverse community-based cohort of 648 young and midlife women from five Michigan communities. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI), a widely used self-report questionnaire with 19 dimensions of sleep. A score 5 on the PSQI was considered indicative of poor sleep quality. Fasting lipids levels were assessed in plasma for all women. Based on clinical guidelines for dyslipidemia, we classified women by high and low lipid levels; High-density lipoprotein 40 mg/dl, Low-density lipoprotein160 mg/dl, Total Cholesterol 240mg/dl, Triglycerides200mg/dl. Health, sociodemographic and lifestyle information was collected through questionnaires. Next, we grouped women by low and elevated (borderline/high) lipids levels and examined associations with poor sleep quality. Bivariate analysis was used for determining the association between the lipid levels with covariates of interest. Logistic regression models, adjusting for sociodemographic, health and lifestyle characteristics, were utilized to assess the association between poor sleep quality and dyslipidemia. Results Women in this cohort had a mean age of 38y and 68% were white. More than half (60%) reported poor sleep quality. The prevalence of low HDL and high total cholesterol was 41% and 30% respectively. Women with poor sleep quality were more likely to have low HDL (adjusted OR=3.17, 95% CI: 1.78, 6.96) than women with good sleep quality. Associations of poor sleep quality with high levels of triglycerides, LDL, and total cholesterol were not statistically significant. However, when we grouped women by elevated/high levels, we found that high triglycerides and low HDL levels were associated with poor sleep quality (adjusted OR=1.94, 95% CI: 1.06, 3.54) and (adjusted OR=2.65, 95% CI: 1.71, 4.12), respectively. Conclusion In this cohort of young and midlife women, we found significant associations between poor sleep quality, high triglycerides, and low HDL. These findings highlight the potential influence of sleep quality on cardiovascular function among women. Support (if any)