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February 26, 2024Journal of Experimental & Clinical Cancer Research12 citationsOpen Access

Combined inhibition of HER2 and VEGFR synergistically improves therapeutic efficacy via PI3K-AKT pathway in advanced ovarian cancer

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WLWeisong LiKZKai ZhangWWWenjun Wang

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Abstract

Ovarian cancer (OC) is a prevalent malignancy in the female reproductive system, and developing effective targeted therapies for this disease remains challenging. The aim of this study was to use clinically-relevant OC models to evaluate the therapeutic effectiveness of RC48, an antibody-drug conjugate (ADC) targeting HER2, either alone or in combination with the VEGFR inhibitor Cediranib Maleate (CM), for the treatment of advanced OC.

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Cite This Study

Li et al. (2024) studied this question.

synapsesocial.com/papers/68e777acb6db6435876ecb6dhttps://doi.org/10.1186/s13046-024-02981-5
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