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February 19, 2024Journal of Medical Economics2 citationsOpen Access

A matching-adjusted indirect comparison of results from REDUCE and RESPECT—two randomized trials on patent foramen ovale closure devices to prevent recurrent cryptogenic stroke

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SKScott E. KasnerLSLars SøndergaardMNMitesh Nakum

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Abstract

Two randomized clinical trials, REDUCE and RESPECT, demonstrated that patent foramen ovale (PFO) closure in combination with antithrombotic therapy was more effective for the prevention of recurrent ischemic stroke compared with antithrombotic therapy alone. The aim of this study was to determine the relative efficacy and safety of the PFO closure devices used in REDUCE (HELEX and CARDIOFORM Septal Occluders) compared with the device used in RESPECT (Amplatzer PFO Occluder).

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Cite This Study

Kasner et al. (2024) studied this question.

synapsesocial.com/papers/68e78968b6db6435876fbd68https://doi.org/10.1080/13696998.2024.2320604
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1European position paper on the management of patients with patent foramen ovale. General approach and left circulation thromboembolism2018 · 442 citations
  2. 2Transcatheter Closure of Patent Foramen Ovale versus Medical Therapy after Cryptogenic Stroke: A Meta-Analysis of Randomized Controlled Trials2018 · 23 citations
  3. 3Network meta-analysis on patent foramen ovale: is a stroke or atrial fibrillation worse?2020 · 12 citations
  4. 4Patent Foramen Ovale and Cryptogenic Stroke or Transient Ischemic Attack: To Close or Not to Close? A Systematic Review and Meta-Analysis2018 · 48 citations
  5. 5Classification of Stroke Subtypes2009 · 462 citations