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October 20, 20250 citationsOpen Access

PsychBench: A comprehensive and professional benchmark for evaluating the performance of LLM-assisted psychiatric clinical practice

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SLShuyu LiuRWRuoxi WangLZLing Zhang

Key Points

  • Existing models show significant potential but are inadequate for decision-making in psychiatric practice.
  • A quantitative evaluation of 16 LLMs revealed strengths and limitations in their clinical performance.
  • PsychBench provides a comprehensive framework to evaluate LLMs tailored for psychiatric applications.
  • A clinical reader study with 60 psychiatrists suggests notable support for junior psychiatrists using LLMs.

Abstract

The advent of Large Language Models (LLMs) offers potential solutions to address problems such as shortage of medical resources and low diagnostic consistency in psychiatric clinical practice. Despite this potential, a robust and comprehensive benchmarking framework to assess the efficacy of LLMs in authentic psychiatric clinical environments is absent. This has impeded the advancement of specialized LLMs tailored to psychiatric applications. In response to this gap, by incorporating clinical demands in psychiatry and clinical data, we proposed a benchmarking system, PsychBench, to evaluate the practical performance of LLMs in psychiatric clinical settings. We conducted a comprehensive quantitative evaluation of 16 LLMs using PsychBench, and investigated the impact of prompt design, chain-of-thought reasoning, input text length, and domain-specific knowledge fine-tuning on model performance. Through detailed error analysis, we identified strengths and potential limitations of the existing models and suggested directions for improvement. Subsequently, a clinical reader study involving 60 psychiatrists of varying seniority was conducted to further explore the practical benefits of existing LLMs as supportive tools for psychiatrists of varying seniority. Through the quantitative and reader evaluation, we show that while existing models demonstrate significant potential, they are not yet adequate as decision-making tools in psychiatric clinical practice. The reader study further indicates that, as an auxiliary tool, LLM could provide particularly notable support for junior psychiatrists, effectively enhancing their work efficiency and overall clinical quality. To promote research in this area, we will make the dataset and evaluation framework publicly available, with the hope of advancing the application of LLMs in psychiatric clinical settings.

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Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68f6379bb481a140a36cf4f1https://doi.org/10.48550/arxiv.2503.01903
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Psychiatry-Bench: A Multi-Task Benchmark for LLMs in Psychiatry2025
  2. 2Large language models in clinical psychiatry: Applications and optimization strategies2025 · 2 citations
  3. 3CliBench: Multifaceted Evaluation of Large Language Models in Clinical Decisions on Diagnoses, Procedures, Lab Tests Orders and Prescriptions2024 · 2 citations
  4. 4Large language model applications for real-time clinical mental health assessment: Current potential and future directions.2026
  5. 5Evaluating Clinical Competencies of Large Language Models with a General Practice Benchmark2025