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November 30, 2025Chemical Biology & Drug Design

Network Pharmacology and Transcriptomic Analysis Reveal the Mechanism by Which Ginsenoside CK Remodels the Tumor Immune Microenvironment to Inhibit Liver Cancer Progression

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Authors

FYFangzhi YeYWYong WangQDQiaohui Du

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Overview

Analysis reveals ginsenoside CK inhibits cell proliferation in HCC by regulating MAP kinase and tumor immune microenvironment.

Key Points

  • Ginsenoside CK downregulates EZH2, leading to inhibition of HCC cell proliferation and enhancing the tumor immune microenvironment.
  • Flow cytometry and molecular docking confirmed the effects of ginsenoside CK on tumor immune modulation and treatment efficacy.
  • Assessment of protein–protein interaction identified EZH2 as a critical target, influencing immune cell activity and tumor progression.
  • The study highlights the role of MAP kinase in the signaling pathways affecting the tumor immune landscape.

Cite This Study

Ye et al. (2025) studied this question.

synapsesocial.com/papers/692b94341d383f2b2a3786f7https://doi.org/10.1111/cbdd.70204
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