Abstract 39: Hepatic Cancer in Northeastern Brazil: Regional Disparities, Underreporting, and Impact on Incidence and Mortality

Abstract Purpose: To analyze regional disparities in the incidence and mortality of hepatic cancer (HC) in Northeastern Brazil (NE), assessing potential underreporting and the impact of regional inequalities on access to diagnosis and treatment. Methods: This descriptive epidemiological study (2021–2023) utilized data extracted from the Cancer Care Dashboard (Painel-Oncologia), the Mortality Information System (SIM), the Notifiable Diseases Information System (SINAN), the Hospital Information System (SIH), and the National Cancer Institute (INCA). We calculated the ratio of deaths to new cases, incidence and mortality rates, and the discrepancy between hospital records and population-based estimates. We also evaluated in-hospital lethality by examining the proportion of deaths among hospital admissions. Results: During the study period, approximately one quarter of in-hospital deaths from HC in Brazil occurred in the NE, a figure linked to regional determinants including a high prevalence of hepatitis B/C (12% of records), which are major risk factors for the disease. The region accounted for over 25% of hospital admissions for hepatic disease, indicating a substantial disease burden. Conversely, the NE presented the lowest in-hospital mortality rate for HC (21. 73/100, 000) among all regions. However, this does not translate to lower overall lethality, as the NE’s general mortality rate (4. 44) is the country’s third highest. Moreover, the incidence of HC in the NE (5. 07) exceeds the national average (4. 29) by 18%. According to the Cancer Care Dashboard (ICD-10 C22), 2, 131 new hospital cases of HC were recorded in the NE between 2021 and 2023, while 7, 960 in-hospital deaths occurred in the same period—equivalent to 3. 7 in-hospital deaths per new case. Nationally, INCA estimates 10, 700 new annual cases of HC, whereas hospital records indicate a yearly average of only 3, 572 new cases, suggesting underreporting. Conclusion: These findings highlight regional disparities in the burden of HC, with the NE accounting for a large share of deaths and a higher-than-average incidence. The high death-to-new-case ratio suggests late-stage diagnosis. The discrepancy between INCA’s projections and hospital records reinforces the likelihood of underreporting, undermining screening and early detection policies. Expanding access to timely diagnosis and treatment is vital to lower mortality rates and reduce regional inequalities in tackling HC in Brazil. Citation Format: Jéssica M. Bohnenberger, Ana Lúcia S. Rosson, Gabriela G. Dal Alba, Júlia Dorcinio, Luiza N. Candanedo, Mariana S. Afonso, Rafaela C. Pires, Yasmin M. Loureiro. Hepatic Cancer in Northeastern Brazil: Regional Disparities, Underreporting, and Impact on Incidence and Mortality abstract. In: Proceedings of the 13th Annual Symposium on Global Cancer Research; 2025 Sep 16. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34 (12Suppl): Abstract nr 39.