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December 10, 2025JAMA Surgery4 citations

Glucagon-Like Peptide 1 Receptor Agonist Use and Vertebral Fracture Risk in Type 2 Diabetes

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WKWei-Thing KhorKCKuan-Yu ChiHLHong-Min Lin

Key Points

  • This research aims to assess the relationship between GLP-1 receptor agonist use and vertebral fracture risk in individuals with type 2 diabetes.
  • Cohort study design
  • Analyzed prescriptions of semaglutide, liraglutide, or dulaglutide
  • Evaluated occurrences of vertebral fractures and related surgical procedures
  • Increased vertebral fracture risk identified among patients using semaglutide and dulaglutide
  • Related surgical procedures observed in cohort
  • Findings indicate the need for monitoring fracture risk in patients on these medications

Abstract

This cohort study examines the association of semaglutide, liraglutide, or dulaglutide prescriptions with vertebral fractures and related surgical procedures among patients with type 2 diabetes.

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Cite This Study

Khor et al. (2025) studied this question.

synapsesocial.com/papers/69401d412d562116f28f8407https://doi.org/10.1001/jamasurg.2025.5372
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