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December 10, 2025Clinical Cancer Research

Abstract A027: Mode of presentation and symptoms at diagnosis of early- and late-onset colorectal cancer: a large retrospective AI-powered analysis

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Authors

EÖEmerik ÖsterlundBMBerta Martín-CullellSCSebastian Correa Cautino

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Overview

Retrospective analysis shows EOCRC presents symptomatically more often than LOCRC, highlighting screening gaps.

Key Points

  • The aim was to characterize differences in presentation and symptoms at diagnosis between early-onset and late-onset colorectal cancer.
  • Retrospective cohort analysis of colorectal cancer cases diagnosed from 1990 to 2025
  • Used AI-powered classification based on clinical notes validated on 500 samples
  • Compared presentation modes and symptoms using Chi-square and odds ratios
  • 29% of colorectal cancer cases were early-onset and 71% were late-onset
  • Early-onset patients more often presented with symptomatic (72% vs 65%) and emergent cases (23% vs 20%)
  • Symptomatic cases frequently included abdominal/rectal pain (45% vs 35%), while anemia was less common (11% vs 16%)

Cite This Study

Österlund et al. (2025) studied this question.

synapsesocial.com/papers/69401d412d562116f28f84c9https://doi.org/10.1158/1557-3265.earlyonsetca25-a027
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