Herein, we described an efficient gold(I)‐catalyzed redox cycloisomerization/3+2 dipolar cycloaddition domino reaction of o ‐(alkynyl)nitrobenzenes. The domino process involves the in situ generation of α‐oxo gold carbenes via intramolecular redox reactions of alkynes and nitro functional groups, followed by the formation of nitrones and subsequent intramolecular 3+2 dipolar cycloaddition reaction to furnish a diverse array of complex isoxazolidine‐containing polycyclic scaffolds in moderate to good yields, with up to excellent diastereoselectivities.
Zhao et al. (2025) studied this question.