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December 9, 2025AI medicine.0 citationsOpen Access

Large Language Models in Medicine: Application Status and Challenges

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DTDingcheng TianYLYun LiFLFei Li

Key Points

  • This research explores the applications of large language models in healthcare and their challenges.
  • Analyzed the applications of LLMs in clinical diagnosis, medical education, and public education.
  • Discussed data limitations and model training methods affecting LLMs.
  • Explored multi-modal data fusion in medical scenarios.
  • LLMs improve clinical decisionmaking efficiency and optimize medical education.
  • They face challenges like data limitations and regulatory compliance issues.
  • Future directions include advancing evaluation frameworks and personalized capabilities.

Abstract

In recent years, the rapid evolution of large language models (LLMs) has driven revolutionary changes in multiple medical application scenarios, showcasing vast potential. With continuous technological developments, LLMs have made substantial advancements in clinical diagnosis and support, medical education and training, clinical documentation processing, patient interaction and public education, and medical research assistance. This paper first explores the practical applications of LLMs in these medical scenarios, analyzing how LLMs contribute to improving clinical decisionmaking efficiency, optimizing medical education, improving patient interaction, and advancing medical research. The paper then discusses the key technical elements of LLMs in the medical field, including data and knowledge construction, model training methods, and multi-modal data fusion. We also focus on the challenges faced by LLMs in medical applications, including data limitations, model hallucinations, and insufficient standardization of evaluation. Finally, the paper looks ahead to future research directions, highlighting the improvement of evaluation frameworks, the enhancement of personalized medical capabilities, the development of multi-modal medical LLMs, and the strengthening of ethical and regulatory compliance. Through these analyses, this paper aims to advance the ongoing development and practical application of medical LLMs.

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Cite This Study

Tian et al. (2025) studied this question.

synapsesocial.com/papers/69401d5b2d562116f28f8a92https://doi.org/10.53941/aim.2025.100008
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Also Consider

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  1. 1Large Language Models for Medicine: A Survey2024 · 1 citations
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  3. 3Large Language Models in the Medical Field: Principles and Applications2024 · 5 citations
  4. 4Evaluating large language models in medical applications: a survey2024 · 4 citations
  5. 5Large language models in healthcare and biomedical informatics: A comprehensive review2026 · 3 citations