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November 27, 2025Breast Cancer Research0 citationsOpen Access

CAND1 mediates CUL7-dependent HER2 protein stability to drive breast cancer progression

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XHXiaoyue HeYCYuanlin ChenHHHongbiao Huang

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Abstract

In summary, this study highlights the critical role of CAND1 in regulating HER2 ubiquitination and suggests a potential therapeutic strategy for patients with HER2-positive breast cancer.

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Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/69402ff92d562116f2905830https://doi.org/10.1186/s13058-025-02158-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 1392 Identification of CAND1 and CAND2 interacting proteins using BioID2024
  2. 2Prognostic potential of CUL3 ligase with differential roles in luminal A and basal type breast cancer tumors2024 · 1 citations
  3. 3Identification of CAND1 as a DNA-dependent protein kinase-regulated coactivator of androgen receptor and the ARv7 splice variant2026
  4. 4CUL5-mediated ubiquitination in cancer cell therapy: context-dependent roles, molecular networks, and emerging therapeutic avenues2026
  5. 5CUL7-mediated KEAP1 ubiquitination promotes the progression of colon cancer via NRF2 signaling2026