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December 12, 2025Neurology3 citations

Plasma pTau217 and Neurofilament Light Chain as Differentiative Markers for Progressive Supranuclear Palsy From Parkinson Disease

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CLCheng‐Hsuan LiSFSung‐Pin FanPCPin‐Shiuan Chen

Key Points

  • To assess plasma pTau217 and neurofilament light chain as markers to differentiate PSP from PD.
  • Used plasma pTau217 and NfL combined with brain MRI
  • Evaluated the effectiveness of the noninvasive approach
  • Plasma pTau217 and NfL together distinguished PSP from PD
  • Findings support the utility of noninvasive markers in clinical settings

Abstract

The combination of plasma pTau217 and NfL with brain MRI represents a noninvasive and clinically feasible strategy for distinguishing PSP from PD.

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/6941aae10f5af7fd17df59bchttps://doi.org/10.1212/wnl.0000000000214406
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