PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
January 10, 2026BMC Gastroenterology0 citationsOpen Access

Impact of partial hepatectomy versus other major abdominal surgeries on postoperative myocardial injury: a propensity score-matched analysis

ZZZheng ZhangYDYi DuanHHHongyu Huo

Key Result

Partial hepatectomy significantly increases the risk of postoperative myocardial injury compared to other major abdominal surgeries, especially in overweight patients.

Key Points

  • This analysis investigates the risk of postoperative myocardial injury associated with partial hepatectomy compared to other abdominal surgeries.
  • Conducted a propensity score-matched analysis
  • Compared outcomes from partial hepatectomy and other major abdominal surgeries
  • Focused on the impact in overweight patients
  • Partial hepatectomy is linked to a higher risk of postoperative myocardial injury
  • The effect is particularly pronounced in overweight patients

Structured PICO

Does partial hepatectomy increase the risk of myocardial injury after non-cardiac surgery compared to other major abdominal surgeries in adult patients?

P
Population
430 adult patients (propensity score-matched cohort from an initial 864) undergoing partial hepatectomy or other major abdominal surgeries under total intravenous anesthesia with at least one postoperative cardiac troponin measurement. Mean age ~55% <65 years, ~75% male, single-center (South Korea).
I
Intervention
Partial hepatectomy (PH)
C
Comparator
Other major abdominal surgeries (MAS) (intraperitoneal operation with no primary involvement of the thorax, >2 hours duration, >200 ml blood loss)
O
Outcome
Myocardial injury after non-cardiac surgery (MINS), defined as postoperative cTn ≥ 30 ng/L with an absolute increase of ≥ 30 ng/L from baseline and no non-ischemic causesurrogate

Partial hepatectomy is associated with a significantly higher risk of postoperative myocardial injury compared to other major abdominal surgeries, particularly in overweight patients, highlighting the need for enhanced perioperative cardiac monitoring.

Limitations

  • Selection bias due to requiring postoperative troponin measurement, skewing the cohort toward older, higher-risk patients
  • Restricted to in-hospital follow-up, precluding assessment of 30-day and 1-year mortality
  • Single-center South Korean cohort limits generalizability to Western populations
  • Borderline statistical significance (P=0.044) suggests findings are hypothesis-generating
  • Potential unmeasured confounding despite propensity score matching (e.g., liver disease severity, resection extent)

Abstract

Partial hepatectomy is associated with significantly increased risk of postoperative myocardial injury compared with other major abdominal procedures, particularly among overweight patients.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Zhang et al. (2026) studied this question. Partial hepatectomy significantly increases the risk of postoperative myocardial injury compared to other major abdominal surgeries, especially in overweight patients.

synapsesocial.com/papers/696321c091e05aa366cb8027https://doi.org/10.1186/s12876-025-04495-6
Ask AI
Helpful
Bookmark
Share
View Full Paper