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January 10, 2026Frontiers in Nutrition0 citationsOpen Access

Unraveling the multifaceted benefits of physical exercise: a comprehensive review of body composition, metabolic regulation, and systemic health

SZShengxuan ZhangILInmaculada Xu LouSDSammit Vishram Deshpande

Key Result

Incorporating tailored physical exercise, such as HIIT or MICT, significantly aids weight management and improves metabolic health in individuals with obesity.

Key Points

  • This review aims to explore the multifaceted benefits of physical exercise on body composition and metabolic health in individuals affected by obesity.
  • Analyzed recent literature from the past 5 years focusing on physical exercise and obesity.
  • Reviewed various forms of physical exercise including HIIT and MICT.
  • Examined how exercise combined with dietary management influences weight control.
  • Physical exercise affects weight loss and adipose tissue reduction.
  • Improved body composition and metabolic outcomes were noted, such as better insulin regulation.
  • Exercise enhances cardiorespiratory function and psychological well-being.

Structured PICO

Does physical exercise improve body composition, metabolic regulation, and systemic health in individuals with obesity?

P
Population
Human populations focusing on the effects of physical exercise on overall health and obesity, based on studies published between 2019 and 2024.
I
Intervention
Physical exercise (including High-Intensity Interval Training [HIIT], Moderate-Intensity Continuous Training [MICT], and resistance training), with or without dietary modifications.
O
Outcome
Effects on weight loss, adipose tissue reduction, body composition, metabolism, physical capacity, cardiorespiratory function, insulin regulation, inflammation, psychological adaptations, hormonal balance, and gut microbiota.

Targeted exercise interventions, especially when combined with dietary modifications, offer multifaceted benefits for managing obesity and its associated metabolic and cardiovascular complications.

Abstract

Obesity, a significant comorbidity for various cardiovascular and respiratory diseases, demands individualized and effective management strategies. Without appropriate intervention, obesity can severely compromise an individual’s health. Achieving weight management is feasible through the application of evidence-based knowledge and sustained commitment. Incorporating diverse forms of physical exercise—such as High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT)—in combination with tailored dietary habits can optimize outcomes for affected individuals. In fact, dietary regulation remains the cornerstone of any weight management program, especially among adolescents and adults facing modern lifestyle challenges. When paired with an exercise regimen aimed at reducing adipose tissue, this combined approach effectively facilitates weight control. Moreover, obesity is characterized by chronic low-grade systemic inflammation and is closely linked to numerous metabolic disorders, including the highly prevalent Diabetes Mellitus. This connection is largely attributable to obesity’s profound impact on hormonal regulation, particularly in the development of insulin resistance. For individuals who are unable to manage their weight through conventional means, bariatric surgery may be considered in advanced cases. However, post-surgical care—comprising proper dietary management and regular physical exercise—is essential for achieving and maintaining favorable outcomes. In this literature review, recent articles from the past 5 years examining the benefits of physical exercise on obesity were analyzed. The findings reveal that different modalities of physical exercise influence weight loss, adipose tissue reduction, body composition, metabolism, physical capacity, cardiorespiratory function, insulin regulation, inflammation, psychological adaptations, hormonal balance, gut microbiota, as well as factors related to pregnancy and aging. Notably, the benefits derived from physical exercise vary according to the specific type of activity performed. Consequently, when prescribing an exercise regimen, it is crucial to align the program with the individual’s specific therapeutic objectives.

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Cite This Study

Zhang et al. (2026) studied this question. Incorporating tailored physical exercise, such as HIIT or MICT, significantly aids weight management and improves metabolic health in individuals with obesity.

synapsesocial.com/papers/696321d491e05aa366cb8198https://doi.org/10.3389/fnut.2025.1691690
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