P-2127. Early Post-Lung Transplant (LTx) Infections in the Antimicrobial Prophylaxis Era

Abstract Background Despite widespread antimicrobial prophylaxis, infections remain a common complication after lung transplantation (LTx). This study aimed to identify the occurrence, risk factors, 66.7%), followed by viral (4; 7.8%) 5.8%). Most common site of infection were the lungs [pneumonia (32), tracheobronchitis (6), empyema (4) p=0.003). Positive donor culture/infection was associated with a lower risk of infection given all pt without infection had positive donor cultures. Most infections occurred 2 weeks after LTx, & more frequently among pt on ECMO (p=0.02) (Figure 1A&B). 7 pt died within 90 d after LTx, infection contributed to death in 2 pt. Conclusion Bacterial infections, mainly pneumonia, were most common within 30 d after LTx, ECMO & longer intubation increased the risk of infection. These findings emphasize the need for ongoing evaluation & adjustment of infection prevention strategies, including efforts to reduce invasive procedures after LTx . Positive donor cultures did not increase the risk for infection, likely due to our ongoing notification system. Disclosures Marisa H. Miceli, MD, F2G: PI in clinical trial|GSK: PI clinical trial|Pulmocide: PI in clinical trial|Scynexis: Advisor/Consultant