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January 14, 2026Open Forum Infectious Diseases0 citationsOpen Access

Evaluation of BioFire FilmArray® Pneumonia PCR Multiplex Panel Testing in Routine Outpatient Surveillance Bronchoscopies After Lung Transplant

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NSNeeraja SwaminthanLFLaura FryeKHKimberly Hanson

Key Points

  • To evaluate the effectiveness of BioFire FilmArray pneumonia testing in outpatient surveillance bronchoscopies for lung transplant recipients.
  • Retrospective analysis of outpatient bronchoscopies in lung transplant recipients from October 2023 to April 2025.
  • Data collected on demographics, test results, symptoms, and antibiotic prescriptions.
  • Concordance between PCR panel and bacterial culture assessed using Cohen’s kappa.
  • 215 surveillance bronchoscopies were conducted in 58 lung transplant recipients.
  • PCR identified bacterial targets in 10.6% of cases, while bacterial cultures were positive in 9.3%.
  • High concordance of 96% was observed between PCR and culture results.

Abstract

Abstract Background Lung transplant recipients (LTRs) undergo surveillance bronchoscopies (SB) at regular intervals post-transplant to detect rejection/infection early 70% were male. Most (96%) LTRs were double lung transplants. Median time from transplant to SB was 197 days (IQR 190.8). Only 7% of SBs occurred at a time when a patient had a clinical suspicion of possible LRTI. The PCR resulted with a positive target in 20.5% of BAL specimens,10.6% PCRs had a detected bacterial target, the PCR panel adds cost without clear benefit. Disclosures Hannah Imlay, MD, MS, Recursion pharmaceutical: Stocks/Bonds (Public Company)

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Cite This Study

Swaminthan et al. (2026) studied this question.

synapsesocial.com/papers/6966f2fb13bf7a6f02c0067chttps://doi.org/10.1093/ofid/ofaf695.167
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