Sudomotor dysfunction was significantly associated with increased carotid intima-media thickness (0.56 vs 0.54 mm) and higher vascular age (48 vs 42 years) in adults with type 1 diabetes.
Cross-Sectional (n=299)
No
Does sudomotor dysfunction correlate with increased carotid intima-media thickness and vascular age in adults with type 1 diabetes?
Sudomotor dysfunction is associated with increased carotid intima-media thickness and vascular age in adults with type 1 diabetes, suggesting it may serve as an early, non-invasive marker of subclinical atherosclerosis.
Absolute Event Rate: 0.56% vs 0.54%
p-value: p=0.04
Abstract Adults with type 1 diabetes (T1D) are at increased risk of premature atherosclerosis. Sudomotor dysfunction (SMD), an early manifestation of diabetic neuropathy, may contribute to vascular injury. This cross-sectional study assessed the relationship between sudomotor function (SMF), carotid intima-media thickness (cIMT), and vascular age (VA) in T1D. The study included 299 adults with T1D (137 men), aged 34 (IQR: 25–44) years, disease duration 16 (IQR: 11–25) years, and HbA1c of 7.7 (IQR: 7.0–8.7)%. Sudomotor function was measured with the SUDOSCAN device; abnormal function was defined as Feet ESC < 70 µS (SMD). cIMT was assessed with carotid ultrasound, and VA was derived from cIMT values. Participants with SMD had thicker cIMT 0.56 (IQR: 0.5–0.67) vs 0.54 (0.48–0.52), p = 0.04 and higher VA 48 (36–70) vs 42 (32–58), p = 0.04. We found a negative correlation between Feet ESC and cIMT (Rs = − 0.22, p < 0.001). In a multiple linear regression model adjusted for sex, HbA1c, BMI, and creatinine, reduced Feet ESC remained significantly associated with VA (β = 0.13, p = 0.03), R 2 = 0.065. SMD is associated with increased cIMT and VA in adults with T1D. SMF assessment by SUDOSCAN may represent a rapid, non-invasive tool to identify individuals at higher cardiovascular risk.
Naskręt et al. (2026) conducted a cross-sectional in Type 1 Diabetes (n=299). Sudomotor dysfunction (Feet ESC <70 µS) vs. Normal sudomotor function (Feet ESC ≥70 µS) was evaluated on Carotid intima-media thickness (cIMT) in mm (p=0.04). Sudomotor dysfunction was significantly associated with increased carotid intima-media thickness (0.56 vs 0.54 mm) and higher vascular age (48 vs 42 years) in adults with type 1 diabetes.