Lymphedema is a common condition often resulting from cancer treatment, among other causes, and poses significant impacts on the patient’s quality of life. Given the lack of curative treatments for lymphedema as well as its detrimental and prevalent nature, much growth is needed in the medical understanding and management of this condition. This review seeks to explore the recent literature on lymphedema, focusing on the most novel research. The aim is to identify the latest research on etiology, diagnosis and monitoring, risk factors, prevention, and treatment of lymphedema. A narrative literature review of PubMed articles from the last 3 years was conducted to gather recent advances in lymphedema. With the understanding of the role of inflammation in lymphedema development, the causes of lymphedema are being better understood. Despite still lacking a diagnostic gold standard, multiple assessment tools are in use, and researchers are actively refining optimal methods for diagnosing and monitoring lymphedema. Personal, demographic, cancer-related, and cancer treatment-related risk factors have also been clarified and can help clinicians identify high-risk patients and support early surveillance and intervention. Research on preventive as well as conservative, surgical, pharmacological, and alternative treatment strategies has shown promising results, although more work is required to identify optimal therapeutic strategies. Overall, this review highlights the importance of ongoing research for lymphedema understanding and management.
Eisenberg et al. (2026) studied this question.