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September 15, 2005EP Europace128 citationsOpen Access

Evaluation of left bundle branch block as a reversible cause of non-ischaemic dilated cardiomyopathy with severe heart failure. A new concept of left ventricular dyssynchrony-induced cardiomyopathy

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JBJean Jacques BlancMFMostafa FatemiVBValerie Bertault

Key Result

Resynchronization therapy led to normalization of left ventricular function in patients with long-standing LBBB, suggesting it as a reversible cause of cardiomyopathy.

Key Points

  • To investigate whether left bundle branch block (LBBB) is a reversible cause of non-ischaemic dilated cardiomyopathy in severe heart failure cases.
  • Analyzed patients with non-ischaemic dilated cardiomyopathy and severe heart failure
  • Administered resynchronization therapy and monitored heart function after one year
  • Normalization of left ventricular function observed in a subset of patients after one year post-resynchronization therapy
  • Indicates LBBB could be a newly identified reversible factor in cardiomyopathy

Structured PICO

Does resynchronization therapy improve LV function in patients with non-ischaemic dilated cardiomyopathy and long-standing LBBB?

P
Population
Patients with non-ischaemic dilated cardiomyopathy, severe heart failure, and long-standing LBBB
I
Intervention
Resynchronization therapy
O
Outcome
Normalization of LV functionsurrogate

Long-standing LBBB may be a reversible cause of cardiomyopathy, as evidenced by LV function normalization after resynchronization therapy.

Abstract

Normalization of LV function 1 year after resynchronization therapy in a small but important number of patients suggests that long-standing LBBB may be a newly identified reversible cause of cardiomyopathy.

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Cite This Study

Blanc et al. (2005) studied this question. Resynchronization therapy led to normalization of left ventricular function in patients with long-standing LBBB, suggesting it as a reversible cause of cardiomyopathy.

synapsesocial.com/papers/6970eb022d1b404414ca79achttps://doi.org/10.1016/j.eupc.2005.06.005
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