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August 7, 1980New England Journal of Medicine1,371 citations

Termination of Malignant Ventricular Arrhythmias with an Implanted Automatic Defibrillator in Human Beings

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MMM. MirowskiPRPhilip R. ReidMMMorton M. Mower

Key Result

Implanted automatic defibrillators effectively monitored and terminated malignant ventricular arrhythmias in high-risk patients at Johns Hopkins Hospital.

Structured PICO

Does an implanted automatic defibrillator terminate malignant ventricular arrhythmias in patients at high risk of sudden death?

P
Population
Patients at particularly high risk of sudden death
I
Intervention
Implanted automatic defibrillator
O
Outcome
Termination of malignant ventricular arrhythmias

This landmark pilot study describes the first human implantations of an automatic defibrillator to terminate lethal ventricular arrhythmias.

Abstract

THE development of a clinically applicable, automatic, implantable defibrillator has been described previously.1 This electronic device is designed to monitor cardiac electrical activity, to recognize ventricular fibrillation and ventricular tachyarrhythmias with a sinusoidal wave form, and then to deliver corrective defibrillatory discharges. It is intended to protect patients at particularly high risk of sudden death whenever and wherever they are stricken by these lethal arrhythmias.After extensive preclinical testing, 2 a pilot study of this new technique was recently initiated at The Johns Hopkins Hospital. This article decribes the first three patients in whom the automatic defibrillator was implanted to manage . . .

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Cite This Study

Mirowski et al. (1980) studied this question. Implanted automatic defibrillators effectively monitored and terminated malignant ventricular arrhythmias in high-risk patients at Johns Hopkins Hospital.

synapsesocial.com/papers/69714deaf0a245e8b19d197fhttps://doi.org/10.1056/nejm198008073030607
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A chronically implanted system for automatic defibrillation in active conscious dogs. Experimental model for treatment of sudden death from ventricular fibrillation.1978 · 133 citations
  2. 2Electrical energy requirements for ventricular defibrillation.1978 · 15 citations
  3. 3Transthoracic Ventricular Defibrillation with Triangular and Trapezoidal Waveforms1966 · 117 citations
  4. 4The Development of the Transvenous Automatic Defibrillator1972 · 89 citations
  5. 5The Automatic Implantable Defibrillator: A New Avenue1980 · 3 citations