Unified Approach to Indolosesquiterpene Alkaloids: Total Syntheses of Anti-Viral Agents, Xiamycin A and Oridamycin A

Key Points

• The aim is to establish an effective method for the total synthesis of anti-viral indolosesquiterpene alkaloids xiamycin A and oridamycin A.
• Utilized a unified catalytic asymmetric total synthesis approach.
• Employed In(III)-catalyzed regio- and diastereoselective ene-yne cyclization.
• Focused on optimizing conditions for cyclization to enhance yield and selectivity.
• Successfully synthesized xiamycin A and oridamycin A.
• Achieved high regioselectivity and diastereoselectivity in the cyclization step.
• Demonstrated practical application for producing valuable anti-viral compounds.