Enhancing Tumor ROS Generation via Nanozyme-Amplified Photodynamic Therapy with Oxygen-Supplying Bacterial OMVs

Key Points

• The aim is to investigate how bacterial outer membrane vesicles can enhance tumor-specific reactive oxygen species generation during photodynamic therapy.
• Utilized bacterial outer membrane vesicles as carriers in photodynamic therapy.
• Applied nanozyme to amplify reactive oxygen species production.
• Assessed the accumulation of vesicles in tumor tissues and their immunostimulatory effects.
• Significantly increased reactive oxygen species generation in tumor cells with nanozyme addition.
• Improved tumor-targeting capabilities of the outer membrane vesicles observed.
• Enhanced immunological response noted in presence of the bacterial vesicles.