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January 22, 2026New Journal of Chemistry0 citations

Structurally Precise Cationic Polythiophene–b–Polyglutamate Diblock Copolymers with Tunable Polyplex Morphologies for Efficient PCI–Mediated Gene Delivery

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CZChi ZhangXLXuefei LiXZXiangkun Zhang

Key Points

  • The aim is to develop new gene delivery vectors using cationic polythiophene-b-polyglutamate diblock copolymers.
  • Synthesis of cationic polythiophene–b–polyglutamate diblock copolymers
  • Characterization of polymer structures
  • Assessment of gene delivery efficiency and morphology changes
  • New copolymers show effective gene delivery capabilities
  • Diverse polyplex morphologies are tunable through polymer design
  • Photoactivation enhances gene delivery efficiency

Abstract

A new class of structurally defined cationic polythiophene–b–polyglutamate diblock copolymers (P3ETn–b–PBLGm(DET)s) has been developed as molecularly integrated, photoactivatable gene delivery vectors. Through Kumada catalyst–transfer polycondensation (KCTP), the conjugated P3ET block...

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6971be50642b1836717e2f65https://doi.org/10.1039/d5nj04445f
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