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January 22, 2026MedicineOpen Access

Exploring the genetic link between type 2 diabetes and its complications and esophageal malignancy: A Mendelian randomization study

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Authors

MLMingzhi LinCLChongrui LiBLBin Li

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Overview

Mendelian randomization shows a causal link between type 2 diabetes and esophageal malignancy, highlighting health risks.

Key Points

  • This study investigates the causal effect of type 2 diabetes and its complications on esophageal malignancies.
  • Conducted a Mendelian randomization study
  • Utilized genetic variation as an instrumental variable
  • Pooled data from European and Finnish databases
  • Performed multivariate MR analysis to control for confounders
  • Identified a causal relationship between type 2 diabetes and esophageal malignancies (odds ratio = 1.36)
  • Adjusted analysis revealed continued significance of T2D (odds ratio = 1.31)
  • Indicated a clear risk with T2D despite controlling for factors like BMI and hypertension

Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/6971bfdff17b5dc6da021f10https://doi.org/10.1097/md.0000000000047202
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