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January 22, 2026Lab on a Chip3 citations

EV-Blade: an automated centrifugal-pneumatic cartridge for size- and affinity-based exosome isolation from whole blood

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LPLucas PonceletNational Academies of Sciences, Engineering, and MedicineKMKeith MortonNational Academies of Sciences, Engineering, and MedicineMSMatthew ShiuNational Academies of Sciences, Engineering, and Medicine

Key Points

  • The aim is to develop an automated system for efficient exosome isolation from whole blood.
  • Designed an automated centrifugal-pneumatic cartridge.
  • Focused on size- and affinity-based exosome isolation.
  • Tested the system using whole blood samples.
  • Successfully isolated exosomes with high purity.
  • Demonstrated effectiveness in cancer biomarker applications.
  • Improved efficiency compared to traditional methods.

Abstract

Extracellular vesicles (EVs), especially the exosome sized subset are increasingly exploited as minimally invasive cancer biomarkers. These small vesicles are abundant in biofluids and play crucial roles in intercellular communication...

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Cite This Study

Poncelet et al. (2026) studied this question.

synapsesocial.com/papers/6971bfdff17b5dc6da021f69https://doi.org/10.1039/d5lc00977d
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