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January 23, 2026Chemical Science2 citationsOpen Access

Photocatalytic remote C( sp 3 )–H alkylation of long-chain alkenes: A tandem multicomponent approach via radical translocation

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KGKrishna Gopal GhoshDDDebabrata DasVSVinjamuri Srinivasu

Key Points

  • The aim is to explore a new method for organic synthesis that integrates photocatalytic remote C(sp3)–H alkylation with perfluoroalkylation.
  • Developed a transition metal-free tandem multicomponent reaction.
  • Combined perfluoroalkylation with remote C(sp3)–H alkylation.
  • Utilized photocatalysis to facilitate the reaction.
  • Successfully synthesized long-chain alkenes with remote C(sp3)–H alkylation.
  • Achieved a redox-neutral reaction environment without transition metals.
  • Demonstrated high efficiency and selectivity in the reaction.

Abstract

A breakthrough in organic synthesis has been accomplished by developing a redox-neutral, transition metal-free tandem multicomponent reaction that combines perfluoroalkylation with remote C( sp 3 )–H alkylation of terminal alkenes. This method exhibits...

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Cite This Study

Ghosh et al. (2026) studied this question.

synapsesocial.com/papers/69730f34c8125b09b0d1f060https://doi.org/10.1039/d5sc08683c
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