Moderate tricuspid regurgitation (ERO ≥0.4 cm2) is linked to reduced survival and more cardiac events in patients with systolic dysfunction.
Is a specific threshold of tricuspid regurgitation severity associated with reduced survival and increased cardiac events in patients with systolic dysfunction?
In patients with systolic dysfunction, functional tricuspid regurgitation with an ERO ≥0.4 cm2 is the critical threshold associated with reduced survival and increased cardiac events.
Tricuspid regurgitation, even moderate, is associated at diagnosis with more severe heart failure presentation. While moderate TR is associated with heart failure at presentation, our quantitative data show that the threshold associated with reduced survival and more cardiac events is ERO ≥0.4 cm2. These data emphasize the clinical impact of functional TR and warrant large cohort-analysis and clinical trials of treatment of TR associated with left ventricular dysfunction.
Topilsky et al. (2018) studied this question. Moderate tricuspid regurgitation (ERO ≥0.4 cm2) is linked to reduced survival and more cardiac events in patients with systolic dysfunction.