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January 24, 20263 citations

A PNPLA3-NACC1-RIPK3 pathway mediates macrophage necroptosis and inflammation in MASLD.

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XWXinjia WangLBLu BianZFZhuoying Feng

Key Points

  • To investigate how the PNPLA3 148M variant influences inflammation and necroptosis in macrophages related to MASLD.
  • Analyzed the macrophage-specific NF-κB-NACC1-RIPK3 signaling pathway
  • Assessed the role of the PNPLA3 variant in enhancing necroptosis
  • Evaluated hepatocyte steatosis and HSC activation in the context of inflammation
  • The PNPLA3 148M variant leads to increased necroptosis in macrophages
  • Enhanced inflammatory signaling significantly exacerbates hepatocyte steatosis
  • NACC1 is identified as a potential therapeutic target for individuals with the PNPLA3 variant.

Abstract

The PNPLA3 148M variant promotes MASLD through a macrophage-specific NF-κB-NACC1-RIPK3 axis that enhances necroptosis and inflammatory signaling, thereby exacerbating hepatocyte steatosis and HSC activation. NACC1 emerges as a tractable therapeutic target for genetically at-risk individuals.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69746126bb9d90c67120b03fhttps://doi.org/10.1097/hc9.0000000000000890
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