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January 24, 2026Reaction Chemistry & Engineering3 citations

Controlling explosive and highly energetic reactions: scaling up the liquid-phase aerobic oxidation of alcohols and aldehydes in flow

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BGBoris GuicheretUniversité Claude Bernard Lyon 1MDMarco Antonio Dos-SantosUniversité Claude Bernard Lyon 1CBClaude de BellefonUniversité Claude Bernard Lyon 1

Key Points

  • The study aims to explore the scalability of aerobic oxidation of alcohols and aldehydes using multiphasic continuous-flow reactors.
  • Utilization of multiphasic continuous-flow reactors
  • Assessment of aerobic oxidation reactions
  • Evaluation of sustainability metrics
  • Improved efficiency of alcohol and aldehyde oxidation
  • Enhanced sustainability compared to batch processes
  • Feasibility demonstrated at pilot-scale operations

Abstract

Multiphasic continuous-flow reactors can improve the sustainability of the synthesis of active pharmaceutical ingredients (APIs). Although this technology has been proven at the laboratory scale, its implementation at the pilot...

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Cite This Study

Guicheret et al. (2026) studied this question.

synapsesocial.com/papers/69746126bb9d90c67120b0edhttps://doi.org/10.1039/d5re00444f
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