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January 24, 20260 citations

Multi-Omics and Network Pharmacology Reveal Calycosin as a Candidate Metabolic Modulator in COPD.

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YYYang YangSecond Affiliated Hospital of Hunan University of Traditional Chinese MedicineXTXiong TanHunan University of Traditional Chinese Medicine

Key Points

  • The research aims to identify metabolic pathways involved in COPD and propose calycosin as a therapeutic candidate.
  • Conducted multi-omics analysis to assess metabolic pathway changes.
  • Identified specific alterations in pyruvate and glyoxylate/dicarboxylate metabolism.
  • Applied network pharmacology to evaluate calycosin's therapeutic potential.
  • Highlighted key metabolic perturbations linked to COPD pathophysiology.
  • Proposed calycosin as a modulator for metabolic pathways related to COPD.
  • Established metabolic dysregulation as a central target for COPD treatment.

Abstract

This integrated analysis highlights distinct metabolic pathway perturbations, specifically in pyruvate and glyoxylate/dicarboxylate metabolism, as key components of COPD pathophysiology and proposes calycosin as a mechanistically grounded candidate for modulating these pathways. This work shifts focus towards metabolic dysregulation as a central therapeutic target, providing a foundation for developing novel strategies to manage COPD beyond symptom control.

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Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69746149bb9d90c67120b22ahttps://doi.org/10.2174/0113862073403083251019173458
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