Single-shot pulsed field ablation did not show superior efficacy over point-by-point radiofrequency ablation in achieving freedom from atrial arrhythmias.
Does single-shot pulsed field ablation improve single-procedure freedom from atrial arrhythmias compared to point-by-point radiofrequency ablation in patients with paroxysmal atrial fibrillation?
In patients with paroxysmal atrial fibrillation, single-shot pulsed field ablation was not superior to radiofrequency ablation for arrhythmia-free efficacy, though it was associated with fewer safety events.
This randomized trial performed in patients with paroxysmal AF did not demonstrate superior efficacy of single-shot PFA vs point-by-point RFA using the CLOSE protocol regarding single-procedure freedom from atrial arrhythmias, despite fewer safety events being observed in this study with PFA.
Jais et al. (2026) studied this question. Single-shot pulsed field ablation did not show superior efficacy over point-by-point radiofrequency ablation in achieving freedom from atrial arrhythmias.