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Synapse
January 24, 2026Revue Médicale Suisse0 citations

Effets indésirables neurologiques des inhibiteurs de points de contrôle immunitaire

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PLPeter Lermen

Key Points

  • To explore the neurological adverse effects associated with immune checkpoint inhibitors and provide management strategies.
  • Reviewed existing literature on immune-related adverse events (irAEs) related to neurological effects.
  • Discussed evidence-based management strategies for prevention, diagnosis, and treatment of irAEs.
  • Outlined decision criteria for resuming immune checkpoint inhibitor therapy post-irAE.
  • Neurological complications from immune checkpoint inhibitors can arise from excessive immune responses.
  • A comprehensive management approach can mitigate the impact of these neurological adverse effects.
  • Clear criteria for treatment resumption can enhance patient safety following an irAE.

Abstract

Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment and significantly improved survival in many tumour types. However, blocking the immune system's inhibitory signaling pathways can trigger an excessive immune response against the body's own tissues, leading to immune-related adverse events (irAEs). These can potentially affect any organ system and represent a significant clinical challenge. This article provides a practical overview of irAEs management, with a particular focus on neurological complications. It presents evidence-based strategies for prevention, diagnosis and treatment, and discusses decision criteria for resuming ICI treatment after an irAE.

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Cite This Study

Peter Lermen (2026) studied this question.

synapsesocial.com/papers/69746187bb9d90c67120b57ehttps://doi.org/10.53738/revmed.2026.22.946.48199
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Also Consider

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