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May 19, 2004New England Journal of Medicine5,848 citations

Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure

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MBMichael R. BristowLSLeslie A. SaxonJBJohn Boehmer

Key Result

Cardiac-resynchronization therapy significantly reduces mortality in advanced heart failure patients when combined with an implantable defibrillator.

Key Points

  • This research aims to evaluate the effectiveness of cardiac-resynchronization therapy alone versus in combination with an implantable defibrillator in patients with advanced heart failure.
  • Participants included patients with advanced heart failure and a prolonged QRS interval.
  • The study tested cardiac-resynchronization therapy with and without an implantable defibrillator.
  • Outcomes assessed included mortality and hospitalization rates.
  • Cardiac-resynchronization therapy significantly decreased the risk of death from any cause.
  • Combining therapy with an implantable defibrillator significantly reduced mortality rates.

Structured PICO

Does cardiac-resynchronization therapy with or without an implantable defibrillator reduce the combined risk of death or hospitalization and mortality in patients with advanced heart failure and a prolonged QRS interval?

P
Population
Patients with advanced chronic heart failure and a prolonged QRS interval
I
Intervention
Cardiac-resynchronization therapy with or without an implantable defibrillator
O
Outcome
Combined risk of death from any cause or first hospitalization, and mortalitycomposite

In patients with advanced heart failure and a prolonged QRS interval, cardiac-resynchronization therapy reduces death or hospitalization, and adding a defibrillator further reduces mortality.

Abstract

In patients with advanced heart failure and a prolonged QRS interval, cardiac-resynchronization therapy decreases the combined risk of death from any cause or first hospitalization and, when combined with an implantable defibrillator, significantly reduces mortality.

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Cite This Study

Bristow et al. (2004) studied this question. Cardiac-resynchronization therapy significantly reduces mortality in advanced heart failure patients when combined with an implantable defibrillator.

synapsesocial.com/papers/697817fb78c42d0bce33a074https://doi.org/10.1056/nejmoa032423
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