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February 2, 2026Stroke0 citations

The SPAN Score as a Primary Outcome in Preclinical Randomized Stroke Trials

Abstract A092: The SPAN Score as the Primary Outcome for Multicenter Preclinical Randomized Controlled Stroke Trials

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Authors

SASanem A AykanTITakahiko ImaiXJXUYAN JIN

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Overview

Multicenter preclinical randomized trials evaluate the SPAN score as a primary outcome for stroke severity assessment, suggesting its effectiveness.

Key Points

  • This study aims to evaluate the SPAN score as a standardized primary outcome in stroke trials by assessing its validity and performance across different cohorts.
  • Analyzed data from SPAN 2.0, 2.1, and 2.2 cohorts.
  • Conducted MCAO on mice for varied time intervals to assess injury severity.
  • Performed survival analysis using Kaplan–Meier curves and Cox models.
  • Utilized Receiver Operating Characteristic (ROC) analysis to validate the SPAN score's distinction between stroke and non-stroke cases.
  • Survival was significantly higher in mice with 30-minute MCAO compared to 60-minute MCAO (p = 0.04).
  • The SPAN score indicated worse outcomes for the 60-minute group (p = 0.036).
  • The score effectively differentiated between impairment in aged versus diabetic and young healthy mice (p = 0.022 and p < 0.001, respectively).
  • ROC analysis confirmed the SPAN score's discriminative abilities with AUC values indicating high validity (AUC = 0.747 and AUC = 0.774 for varying infarct sizes).

Cite This Study

Aykan et al. (2026) studied this question.

synapsesocial.com/papers/6980fc55c1c9540dea80e14ahttps://doi.org/10.1161/str.57.suppl_1.a092
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